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Procedures to estimate other ratios such as risk (prevalence) ratios, odds ratios, hazard ratios, ratios of means are mentioned in the list of Frequently-Asked for Statistics. There are two methods for obtaining the confidence limits for a ratio of linear combinations of model parameters — the method using Fieller's theorem and the delta method. The third argument is the covariance matrix of the coefficients. The transformation can generate the point estimates of our desired values, but the standard errors of these point estimates are not so easily calculated. http://noticiesdot.com/standard-error/delta-method-standard-error-example.php

Potency, intercept=no) Notice that the confidence **limits using Fieller's method** are slightly different from those produced above by the delta method. Ratio Estimate LCL UCL Drug N ED50 1.64934 0.82357 They can, however, be well approximated using the delta method. The confidence level can be changed by specifying the ALPHA= option. %Fieller(data=parms, out=DN, num=-1 0 0, den=0 0 1, label=Drug N ED50, intercept=no) %Fieller(data=parms, out=DS, num=0 -1 0, den=0 0 1, Two methods (Fieller's theorem and the delta method) for obtaining confidence limits for a ratio of linear combinations of model parameters are discussed and illustrated.Type:Usage NotePriority:Topic:Analytics ==> Analysis of VarianceAnalytics ==>

Since you are fitting this as having a gaussian distribution with additive errors on the log scale, the marginal model should work. deltamethod(~ x1 + 5.5*x2, coef(m1), vcov(m1)) ## [1] 0.137 Success! If omitted, the data set name is RatioCI.

The delta method is **a general method** that provides an approximate estimate of the variance of nonlinear functions of random variables. We can then take the variance of this approximation to estimate the variance of \(G(X)\) and thus the standard error of a transformed parameter. The following statements fit the same logistic model as above and estimate the ED50 for each drug using Fieller's method. Standard Deviation Sas proc probit data=assay log; class drug(ref="N"); model ndead/total = drug dose / inversecl(prob=.5) d=logistic; run; proc probit data=assay log; class drug(ref="S"); model ndead/total = drug dose / inversecl(prob=.5) d=logistic; run; Note

One such tranformation is expressing logistic regression coefficients as odds ratios. Standard Error Sas Proc Means data delta; set delta; Ratio=label; LCL=Lower; UCL=Upper; type="Delta "; keep Ratio Estimate LCL UCL type; run; data fieller; length Ratio $ 20; type="Fieller"; set DN DS RP; run; data RatioCIs; length Regression coefficients are themselves random variables, so we can use the delta method to approximate the standard errors of their transformations. http://www.ats.ucla.edu/stat/r/faq/deltamethod.htm Quantal bioassay example Stokes et.

While the estimates of the means can be calculated using the anti-log of the results, I am not sure if the same procedure can be applied to calculate the standard errors Confidence Interval Sas Although the delta method is often appropriate to use with large samples, this page is by no means an endorsement of the use of the delta method over other methods to The estimate and confidence interval on the dose scale can be obtained by exponentiating these values. and Lye, J. (2010), **"A Geometric Comparison of** the Delta and Fieller Confidence Intervals," The American Statistician, 64:3, 234-241.

In this example we would like to get the standard error of a relative risk estimated from a logistic regression. http://www.sas-programming.com/2009/12/applying-delta-method-in-sas.html By default, the INVERSECL option provides effective dose estimates for a range of response rates. Delta Method Sas Code However, when these signs differ and the precision of the denominator is low, the Fieller interval should be used." They conclude that: "... Calculate Standard Error In Sas Here we read in the data and use factor to declare the levels of the honors such that the probability of "enrolled" will be modeled (R will model the probability of

Adjusted predictions are functions of the regression coefficients, so we can use the delta method to approximate their standard errors. http://noticiesdot.com/standard-error/delta-method-standard-error-matlab.php Thus if SE=0.3 on the natural log scale, the std err is exp(0.3)-1 = 35% on the original scale.PG PG Message 2 of 9 (1,884 Views) Reply 1 Like SteveDenham Super We can think of y as a function of the regression coefficients, or \(G(B)\): $$ G(B) = b_0 + 5.5 \cdot b_1 $$ We thus need to get the vector of This will give the least squares mean and standard error on the original scale. Robust Standard Error Sas

**Thanks. **Communities SAS/GRAPH and ODS Graphics Register · Sign In · Help Data visualization with SAS programming Join Now CommunityCategoryBoardLibraryUsers turn on suggestions First, we should define the conditional probability in terms of the regression coefficients. http://noticiesdot.com/standard-error/delta-method-standard-error-calculation.php codes: 0 '***' 0.001 '**' 0.01 '*' 0.05 '.' 0.1 ' ' 1 ## ## (Dispersion parameter for binomial family taken to be 1) ## ## Null deviance: 231.29 on 199

Hirschberg and Lye (2010) compare the two methods and discuss when they produce similar results. Variance Sas Recall that \(G(B)\) is a function of the regression coefficients, whose means are the coefficients themselves. \(G(B)\) is not a function of the predictors directly. al. (2000) discuss a study on mice comparing two drugs applied at several doses.

vG <- t(grad) %*% vcov(m4) %*% (grad) sqrt(vG) ## [,1] ## [1,] 0.745 With a more complicated gradient to calculate, deltamethod can really save us some time. The standard error is calculated using the delta method.Steve Denham Message 3 of 9 (1,884 Views) Reply 1 Like TD21 Occasional Contributor Posts: 17 Re: Estimating the standard errors of log-transformed We will work with a very simple model to ease manual calculations. T Test Sas See the description of the NLEstimate macro for details about displaying parameter names and using the macro.

Error z value Pr(>|z|) ## (Intercept) -8.3002 1.2461 -6.66 2.7e-11 *** ## read 0.1326 0.0217 6.12 9.5e-10 *** ## --- ## Signif. The data are presented below. vG <- t(grad) %*% vb %*% grad sqrt(vG) ## [,1] ## [1,] 0.137 It turns out the predictfunction with se.fit=T calculates delta method standard errors, so we can check our calculations his comment is here The NLEstimate macro uses the fitted model information saved with the STORE statement in PROC LOGISTIC.

References Hirschberg, J. data fd; length label f $32767; infile datalines delimiter=','; input label f; datalines; Drug S ED50,-b_p2/b_p3 Drug N ED50,-b_p1/b_p3 N:S Rel. proc logistic data=assay outest=parms covout; class drug / param=glm; model ndead/total = drug ldose / noint; store out=assaymod; run; proc print noobs; run; Analysis of Maximum Likelihood Estimates Parameter Thanks.1.)PROC SORT DATA = WORK.LOGKsat_MID_TRK_Pre_Post;By Block Point Sample Depth LOC Harvest;RUN;ODS GRAPHICS ON;PROC MIXED DATA = WORK.LOGKsat_MID_TRK_PrePost plots(only)=(ResidualPanel(marginal))PLOTS (MAXPOINTS = 2000000);CLASS Block POINT SAMPLE DEPTH LOC Harvest;MODEL LG_Ksat=Harvest|LOC|DEPTH/DDFM = Satterthwaite RESIDUAL;RANDOM

By default, the macro produces a 95% confidence interval corresponding to an alpha level of 0.05. Using, product rule and chain rule, we obtain the following partial derivatives: $$ \frac{dG}{db_0} = -exp(-b_0 - b_1 \cdot X2) \cdot p1 + (1 + exp(-b_0 - b_1 \cdot X2)) \cdot Zerbe, G.O. (1978), "On Fieller's Theorem and the General Linear Model", The American Statistician, 32:3, 103-105. when the Fieller and Delta intervals differ, the Fieller interval results in better coverage, and in some cases, this advantage can be very large." In this case, the estimated ratios are

Then we will get the ratio of these, the relative risk. Your write the functions to be estimated using the parameter names. The first two ESTIMATE statements estimate the ED50 for each drug, and the relative potency is estimated by the third ESTIMATE statement. The INVERSECL option estimates the effective dose for the drug that is treated as the reference level.

Note that the Fieller intervals are not necessarily symmetric about the ratio estimate. __________ Note 1: PROC PROBIT can fit probit or logistic models. Examples include manual calculation of standard errors via the delta method and then confirmation using the function deltamethod so that the reader may understand the calculations and know how to use This data set is displayed by the PROC PRINT step. The data set created by the OUTEST= and COVOUT options in PROC LOGISTIC should be specified in the DATA= option.

How to cite this page Report an error on this page or leave a comment The content of this web site should not be construed as an endorsement of any particular library(msm) **Version info: **Code for this page was tested in R version 3.1.1 (2014-07-10)

On: 2014-08-01

With: pequod 0.0-3; msm 1.4; phia 0.1-5; effects 3.0-0; colorspace 1.2-4; RColorBrewer 1.0-5; For a random variable \(X\) with known variance \(Var(X)\), the variance of the transformation of \(X\), \(G(X)\) is approximated by: $$ Var(G(X)) \approx \nabla G(X)^T \cdot Cov(X) \cdot \nabla G(X) $$ My first thought would be as follows.

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